Rifaximin (CAS No. 80621-81-4) is a semi-synthetic, non-systemic antibiotic belonging to the rifamycin class. Manufactured by Zhengzhou Minzhong Pharmaceutical Co., Ltd., a leading pharmaceutical company, Rifaximin is globally recognized for its efficacy in treating gastrointestinal disorders. This article explores its applications, mechanisms, safety profile, and the strengths of Zhengzhou Minzhong’s production standards.
What is Rifaximin?
Rifaximin is a broad-spectrum antibiotic that targets gram-positive and gram-negative bacteria in the gut. Unlike systemic antibiotics, it remains largely within the intestinal tract, minimizing systemic side effects. Its unique lipophilic properties allow it to act locally, making it ideal for conditions linked to bacterial overgrowth or dysbiosis.
Key Applications of Rifaximin
- Hepatic Encephalopathy (HE):
Rifaximin is FDA-approved for reducing ammonia levels in cirrhotic patients, preventing HE recurrence. Studies show it significantly improves cognitive function and quality of life. - Irritable Bowel Syndrome (IBS):
Approved for IBS-D (diarrhea-predominant), it alleviates bloating, abdominal pain, and stool frequency by modulating gut microbiota. - Small Intestinal Bacterial Overgrowth (SIBO):
Effective in eradicating SIBO, a condition linked to malabsorption and chronic diarrhea. - Traveler’s Diarrhea:
Mitigates symptoms caused by non-invasive pathogens like Escherichia coli.
Mechanism of Action
Rifaximin inhibits bacterial DNA-dependent RNA polymerase, disrupting transcription and halting protein synthesis. Its poor absorption ensures high luminal concentrations, targeting pathogens without systemic exposure.
Safety and Tolerability
- Low Systemic Absorption: Minimal risk of organ toxicity.
- Well-Tolerated Profile: Common side effects (nausea, headache) are mild and transient.
- Antibiotic Resistance: Limited impact on systemic flora reduces resistance development.
Why Choose Zhengzhou Minzhong Pharmaceutical?
- Quality Assurance:
Adheres to cGMP standards, ensuring batch consistency and purity. - Regulatory Compliance:
Products meet FDA, EMA, and NMPA requirements, with certifications like ISO 9001. - Research-Driven Approach:
Invests in clinical studies to optimize efficacy and safety profiles.
Conclusion
Rifaximin (CAS 80621-81-4) by Zhengzhou Minzhong Pharmaceutical is a cornerstone therapy for gastrointestinal conditions, combining targeted action with a strong safety profile. Backed by rigorous manufacturing standards, it remains a trusted choice for clinicians and patients worldwide.
Rifaximin
CAS No. 80621-81-4
An interactive resource on the premier gut-selective antibiotic, proudly manufactured by Zhengzhou Minzhong Pharmaceutical Co., Ltd.
Product Overview
This section provides a comprehensive introduction to Rifaximin (CAS No. 80621-81-4), a semi-synthetic antibiotic derived from rifamycin. Explore its unique mechanism of action and understand why its non-systemic, gut-selective profile makes it a cornerstone therapy for various gastrointestinal disorders.
A Gut-Selective Antibiotic
Rifaximin sets itself apart through its unique non-systemic, gut-selective profile. With minimal absorption from the gastrointestinal tract (<0.4%), it delivers potent antimicrobial action directly where it's needed—within the gut lumen. This localized activity significantly reduces the risk of systemic side effects associated with many other antibiotics, making it a highly valued agent in modern medicine.
Mechanism of Action
Its primary function is to inhibit bacterial RNA synthesis by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase. This action effectively halts bacterial growth and proliferation without impacting human cells, ensuring targeted and safe therapeutic outcomes.
Therapeutic Applications
Discover the primary clinical uses of Rifaximin. Due to its targeted action within the gut, it has become an effective and trusted treatment for a range of gastrointestinal conditions driven by bacterial overgrowth. The following cards highlight its key indications.
Irritable Bowel Syndrome (IBS-D)
Provides significant relief for patients with IBS-D by modulating the gut microbiota and reducing bacteria that contribute to symptoms like bloating, abdominal pain, and diarrhea.
Hepatic Encephalopathy (HE)
Crucial for reducing the recurrence of overt hepatic encephalopathy in patients with advanced liver disease. It suppresses ammonia-producing gut bacteria, protecting brain function.
Traveler's Diarrhea
A first-line treatment for traveler's diarrhea caused by non-invasive strains of *E. coli*. Its rapid, localized action helps resolve symptoms quickly, allowing for a swift return to health.
Technical & Quality Data
For formulators and researchers, this section provides essential technical specifications for our Rifaximin API. We include a detailed table of product characteristics and an interactive chart to visually represent our commitment to high purity standards.
Product Specifications
| Product Name | Rifaximin |
| CAS Number | 80621-81-4 |
| Molecular Formula | C₄₃H₅₁N₃O₁₁ |
| Molecular Weight | 785.9 g/mol |
| Appearance | Reddish-orange crystalline powder |
| Purity (HPLC) | ≥ 99.0% |
| Standard | Conforms to EP/USP standards |
| Certifications | GMP, ISO 9001 |
| Storage | Keep in a dry, well-ventilated place |
API Purity Visualization
Uncompromising Quality & Reliable Supply
Learn why Zhengzhou Minzhong Pharmaceutical is the ideal partner for your Rifaximin API needs. This section details our commitment to global quality standards, our advanced manufacturing capabilities, and our robust supply chain designed to meet your demands consistently and reliably.
Commitment to Quality
Our Rifaximin API is produced under stringent GMP guidelines. We use advanced analytical techniques to ensure every batch meets the highest standards of purity, potency, and consistency.
Advanced Manufacturing
Our state-of-the-art facilities are equipped with modern technology to guarantee process control and scalability. Every step is meticulously documented and validated.
Global Supply Chain
With decades of experience, we have a robust supply chain to serve clients worldwide, ensuring timely delivery and providing comprehensive regulatory support (CoA, DMF).
Frequently Asked Questions & Contact
Here we answer common questions about our Rifaximin API. If you have further inquiries or are ready to discuss your project, please use the contact information provided. Our team is ready to provide the expert support you need.
The CAS number is a unique identifier for Rifaximin. It ensures precise identification for regulatory submissions, quality control, and scientific research, eliminating any confusion with other substances.
Yes. Our Rifaximin API is a high-purity crystalline powder with excellent physical properties suitable for various oral solid dosage formulations, including tablets and capsules.
You can request a sample or a CoA by contacting our sales team through the "Request a Quote" button. We are committed to full transparency and providing all necessary documentation for your quality assurance needs.
Absolutely. We specialize in building long-term partnerships with our clients. Please reach out to our commercial team to discuss your forecasting and supply requirements.
Partner with a Leader in API Manufacturing
Secure your supply of high-quality Rifaximin from a trusted, GMP-certified global leader. Our team is ready to support your formulation, development, and commercial manufacturing needs.
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